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Página de Inicio arrow Artículos Científicos arrow An update on alopecia areata
An update on alopecia areata Imprimir E-Mail
Current Opinion in Pediatrics:
August 2009 - Volume 21 - Issue 4 - p 475-480
doi: 10.1097/MOP.0b013e32832db986
Dermatology: Edited by James Dinulos
An update on alopecia areata
Kos, Liborka; Conlon, Joseph
Abstract
Purpose of review: Alopecia areata is one of the most frequent
organ-restricted autoimmune diseases, yet its pathogenesis is still
unclear. In addition, although alopecia areata often results in
significant psychological distress, effective treatment is lacking.

Recent findings: New potential susceptibility loci have been
implicated, but the strongest evidence points to certain class II
human leukocyte antigen alleles. There is new evidence for the
collapse of hair follicle immune privilege as a key step in the
pathogenesis of alopecia areata. There is also new basic science
evidence for stress as a contributing factor in the development of
alopecia areata. Few treatments for alopecia areata have been well
evaluated in randomized trials.

Summary: Although multiple potential susceptibility loci have been
implicated, the genetics of alopecia areata is still unclear. The role
of any potential environmental contributors is also unclear. Quality
evidence for efficacy of currently used treatments for alopecia areata
is lacking.
 
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