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Página de Inicio arrow Artículos Científicos arrow Predicting risk for early infantile atopic dermatitis by hereditary and environmental factors
Predicting risk for early infantile atopic dermatitis by hereditary and environmental factors Imprimir E-Mail
PAEDIATRIC DERMATOLOGY
Predicting risk for early infantile atopic dermatitis by hereditary
and environmental factors
H-J. Wen, P-C. Chen*, T-L. Chiang†, S-J. Lin‡, Y-L. Chuang§ and Y-L. Guo¶

Early View (Articles online in advance of print)

ABSTRACT
Background Hereditary and environmental factors contribute to the
occurrence of atopic dermatitis (AD). However, the interaction of
these two factors is not totally understood.

Objectives To evaluate the early risk factors for infantile AD at the
age of 6 months and to develop a predictive model for the development
of AD.

Methods In 2005, a representative sample of mother and newborn pairs
was obtained by multistage, stratified systematic sampling from the
Taiwan national birth register. Information on hereditary and
environmental risk factors was collected by home interview when babies
were 6 months old. Multivariate regression analysis was applied to
determine the risk factors for AD in the infants.

Results A total of 20 687 pairs completed the study satisfactorily. AD
was diagnosed in 7·0% of 6-month-old infants by physicians. Parental
asthma, atopic dermatitis and allergic rhinitis, and maternal
education levels were risk factors for AD in infants. Among
environmental factors, fungus on walls at home and renovation/painting
in the house during pregnancy were significantly associated with early
infantile AD. Using these factors, the probability of having infantile
AD was estimated and grouped into low, high and very high. With five
runs of tests in mutually exclusive subsets of this population, the
likelihood of AD for 6-month-old infants was consistent in all the
groups with the predictive model. The highest predicted probability of
AD was 70·1%, among boys with maternal education levels > 12 years,
both parents with AD, renovation and painting of the house during
pregnancy and fungus on walls at home. The lowest probability was
3·1%, among girls with none of the above factors.

Conclusions This investigation provides a technique for predicting the
risk of infantile AD based on hereditary and environmental factors,
which could be used for developing a preventive strategy against AD,
especially among those children with a family history of atopy.

Accepted for publication 29 June 2009
 
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